Mystery of breast cancer risk gene solved, 20 years after its discovery
More than 20 years after scientists revealed that mutations in the BRCA1 gene predispose women to breast cancer, Yale scientists have pinpointed the molecular mechanism that allows those mutations to...
View ArticleScientists capture first image of major brain receptor in action
Columbia University Medical Center (CUMC) researchers have captured the first three-dimensional snapshots of the AMPA-subtype glutamate receptor in action. The receptor, which regulates most electrical...
View ArticleKey tool in DNA repair kit found
Breaks in DNA can cause chromosome rearrangements, abnormalities linked to cancer. Now Yale scientists have identified how the molecule DNA2 helps begin the complex process of repairing these breaks.
View ArticleResearch team helps father discover source of son's disability
The severe learning disabilities of a teenager in the Netherlands were caused by a genetic mutation that affects the function of ribosomes, the cellular protein-making factories crucial to all life....
View ArticleResearch targets medications for those with depression
"The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors," was published in the September issue of the journal Neuropharmacology.
View ArticleHow breast cancer cells slide to metastasis
The spreading of cancer cells from one part of the body to another, a process known as metastasis, is the leading cause of death among cancer patients. A study published April 26 in Biophysical Journal...
View ArticleNew drug candidate ameliorates Alzheimer's and other brain diseases
Professor Armin Giese from the Center for Neuropathology and Prion Research at the LMU Munich and researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen and at the German Center...
View ArticlePromising peptide for TBI, heart attack and stroke
Strokes, heart attacks and traumatic brain injuries are separate diseases with certain shared pathologies that achieve a common end - cell death and human injury due to hypoxia, or lack of oxygen. In...
View ArticleTeam devises ingenious method to attack cancer at its genetic source
MicroRNAs may be tiny—as few as 20 genetic letters, compared to 3 billion in the DNA of a human—but they play a major role in biology, helping to determine which genes are expressed or silenced. In the...
View ArticleResearchers capture images of a protein complex that keeps hearts beating
For years, a multidisciplinary team of Johns Hopkins researchers has tracked an elusive creature, a complex of proteins thought to be at fault in some cases of sudden cardiac death. As they report Nov....
View ArticleDerivatives of a known drug inhibit the replication of a pathogenic coronavirus
Ludwig Maximilian University of Munich researchers have shown that derivatives of a known drug inhibit the replication of a pathogenic coronavirus in cultured human cells. These compounds can now serve...
View ArticleResearchers find promising new angle for drugs to prevent stroke and heart...
Platelets, which allow blood to clot, are at the heart of numerous cardiovascular problems, including heart attacks and stroke. New research has uncovered a key platelet protein that could offer a new...
View ArticleA 'rocking' receptor: Crucial brain-signaling molecule requires coordinated...
Johns Hopkins biophysicists have discovered that full activation of a protein ensemble essential for communication between nerve cells in the brain and spinal cord requires a lot of organized...
View ArticleAntiviral enzyme contributes to several forms of cancer
Researchers at the University of Minnesota have discovered that a human antiviral enzyme causes DNA mutations that lead to several forms of cancer.
View ArticleMemory-boosting chemical identified in mice
Memory improved in mice injected with a small, drug-like molecule discovered by UCSF San Francisco researchers studying how cells respond to biological stress.
View ArticleScientists discover key mechanism that boosts signalling function of neurons...
(Medical Xpress)—Locating a car that's blowing its horn in heavy traffic, channel-hopping between football and a thriller on TV without losing the plot, and not forgetting the start of a sentence by...
View ArticleResearchers solve 20-year puzzle of how heart regulates its beat
(Medical Xpress)—A 20-year puzzle as to how the heart regulates contraction appears to have been solved by researchers from the University of Bristol. The findings, published in the journal Biophysics,...
View ArticlePutting the brakes on Parkinson's: Anle138b prevents clumping of synunclein...
The earliest signs of Parkinson's disease can be deceptively mild. The first thing that movie star Michael J. Fox noticed was twitching of the little finger of his left hand. For years, he made light...
View ArticleIn the earliest stages of arthritis, high-impact exercise may worsen...
Osteoarthritis, which affects at least 20 percent of adults in the United States, leads to deterioration of cartilage, the rubbery tissue that prevents bones from rubbing together. By studying the...
View ArticleCartilage damaged from exercise may aid in early osteoarthritis detection
Osteoarthritis is the most common joint disorder, affecting about one-third of older adults, and currently there is no cure. A study published by Cell Press April 2nd in the Biophysical Journal reveals...
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